Denis Noble was educated at University College London where he obtained his PhD in 1961. This concerned the first computer modelling of the heart and was published in two articles in Nature in 1960. From 1984 to 2004, he was the Burdon Sanderson Professor of Cardiovascular Physiology, Oxford University, a Chair financed by British Heart Foundation. He is now co-Director of Computational Physiology. His research is focussed on using computer models of biological organs and systems to interpret function through from the molecular to the whole body levels. With its international collaborators, his team has used supercomputers to create the first virtual organ, the virtual heart. As Secretary-General of IUPS, he played a major role in launching the Physiome Project, an international project to use computer simulations to create the quantitative physiological models necessary to interpret the genome. He is author of The MUSIC of LIFE (OUP, 2006).