Beyond Molecular Biology – Applying Gene Regulation Network Inference Methods in Ecology

author: Frank Dondelinger, BioSS - Biomathematics & Statistics Scotland
published: April 16, 2009,   recorded: April 2009,   views: 3923
Categories

Slides

Related content

Report a problem or upload files

If you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.
Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Lecture popularity: You need to login to cast your vote.
  Delicious Bibliography

Description

Reconstructing gene regulation networks from gene expression data is an important task in molecular biology for which various network inference methods have been developed. In ecology, species interaction networks serve a similar purpose, in that they show how different species relate to each other. We have investigated the possibility of applying the methods that were developed for gene regulation networks to reconstruct species interaction networks from species abundance data. We used a Lotka-Volterra style simulation model to produce synthetic data based on species interaction networks, and then tried to reconstruct the original network from this data using Bayesian networks, LASSO (Least Absolute Shrinkage and Selection Operator) and SBR (Sparse Bayesian Regression). We also developed extensions to these methods for dealing with the problem of spatial autocorrelation. Our experiments showed that we can retrieve many species interactions, while keeping the false positive rate low. We compared the different methods, and found that LASSO and Bayesian networks perform best.

See Also:

Download slides icon Download slides: licsb09_dondelinger_bmb_01.pdf (1.1 MB)


Help icon Streaming Video Help

Link this page

Would you like to put a link to this lecture on your homepage?
Go ahead! Copy the HTML snippet !

Write your own review or comment:

make sure you have javascript enabled or clear this field: