Evidence Integration in Bioinformatics

author: Phil Long, Sentient Technologies USA LLC
published: Feb. 25, 2007,   recorded: May 2005,   views: 5126


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Biologists frequently use databases; for example, when a biologist encounters some unfamiliar proteins, s/he will use databases to get a preliminary idea of what is known about them. The databases can be often interpreted as lists of assertions. An example is a protein-protein interaction database: each entry is a pair of proteins that are asserted to interact, along with the supporting evidence. Often a candidate for inclusion in such a database can be supported in a variety of fundamentally different ways. A methodological challenge is how to effectively combine these different sources of evidence to make accurate aggregate predictions. Ideas from machine learning are useful for this. I will describe some of the special properties of problems like this, and relevant methods from machine learning, including algorithms based on bayesian networks, boosting and SVMs.

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