Least squares estimation of a transcription regulation model
published: Sept. 5, 2007, recorded: September 2007, views: 188
Report a problem or upload filesIf you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.
Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
The way transcription factors regulate the activity of their target genes is of much interest. Several authors have recently used model based computational approaches to infer concentrations of transcription factor proteins from high throughput gene expression data ([1-3,6-7]. Here, I present an approach explicitly formulated to model periodic biological phenomena, and a least squares framework for parameter estimation of such a model. Such a computational strategy can be used to infer levels of transcription factor activities at the protein level using genes that are regulated by single transcription factors, and then to decipher “transcriptional logic” of genes under regulation by the comboined actions of multiple transcription factors.
Link this pageWould you like to put a link to this lecture on your homepage?
Go ahead! Copy the HTML snippet !