Can particles at the nanoscale result in better drug delivery systems?
published: Jan. 18, 2008, recorded: October 2007, views: 5326
Report a problem or upload filesIf you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.
Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Due to the advances of molecular biotechnology and bioinformatics, there is a strong increase of new candidate drug molecules. However, their transport to the actual site of action and bioavailability are decisive issue. In order to enable adequate delivery of small or larg drug molecules some special formulation will be required. Current advances in material science and nanotechnology promise the development of new generations of drug carriers for these active substances for diagnostic and therapeutic purposes. Today are mostly investigated liposomes, nanoparticles, dendrimers, nanotubes etc. where size, geometry, porosity, dispersity, surface chemistry are highly defined. Carrier composition and structure promises control over biological fate. In the talk three examples studied in our lab will be used to illustrate these points: preparation of drug loaded solid lipid nanoparticles, interactions of nanoparticles with the cells and surfactant selection for adequate nanoparticles production that causes minimal toxicity to HEK 293 cells, while preventing nanoparticles aggregation. These observations indicate that in the design and development of novel nanoparticles for drug delivery a combination of factors such as composition, size and surface properties influence bioavailability, uptake into the cells and toxicity. Current work focuses on systematic variation of these parameters to develop carrier system with designed function.
Link this pageWould you like to put a link to this lecture on your homepage?
Go ahead! Copy the HTML snippet !