I am currently a professor of engineering at the University of Leuven. I do research on computational methods for diagnosis and disease gene discovery in congenital genetic disorders. I teach several bioinformatics courses, mainly focusing on probabilistic models in computational biology. I am an associate editor for IEEE Transactions on Computational Biology and Bioinformatics. I am a co-founder of two spin-off starts of the university (Data4s, now part of Norkom Technologies, specialized in data-mining for the banking industry, and Cartagenia, specialized in IT solutions for clinical genetic diagnosis). I chaired the 2010 edition of the European Conference on Computational Biology.

I received the Master in Electrical Engineering from the Faculte Polytechnique de Mons, Belgium in 1992. Thanks to a Fulbright grant, I went on to complete a Master in Applied Mathematics at Brown University, Providence, Rhode Island. In 1994, I moved back to Belgium at K.U.Leuven ESAT-SCD, where I received the Ph.D. in 1998. Between 1998 and 2005, I was a postdoctoral researcher (FWO-Vlaanderen) and assistant professor at ESAT-SCD, developing our bioinformatics research. In 2003-2004, I was a visiting researcher at the Center for Biological Sequence Analysis at the Technical University of Denmark. Since 2004, I have been a lecturer and professor at ESAT-SCD. I currently coordinate SymBioSys, the K.U.Leuven Center for Computational Systems Biology. I am also the program director of the Master of Bioinformatics.