MARAS: Signaling Multi-Drug Adverse Reactions

author: Xiao Qin, Department of Computer Science, Worcester Polytechnic Institute
published: Oct. 9, 2017,   recorded: August 2017,   views: 1049
Categories

Related content

Report a problem or upload files

If you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.
Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Lecture popularity: You need to login to cast your vote.
  Delicious Bibliography

Description

There is a growing need for computing-supported methods that facilitate the automated signaling of Adverse Drug Reactions (ADRs) otherwise left undiscovered from the exploding amount of ADR reports filed by patients, medical professionals and drug manufacturers. In this research, we design a Multi-Drug Adverse Reaction Analytics Strategy, called MARAS, to signal severe unknown ADRs triggered by the usage of a combination of drugs, also known as Multi-Drug Adverse Reactions (MDAR). First, MARAS features an efficient signal generation algorithm based on association rule learning that extracts non-spurious MDAR associations. Second, MARAS incorporates contextual information to detect drug combinations that are strongly associated with a set of ADRs. It groups related associations into Contextual Association Clusters (CACs) that then avail contextual information to evaluate the significance of the discovered MDAR Associations. Lastly, we use this contextual significance to rank discoveries by their notion of interestingness to signal the most compelling MDARs. To demonstrate the utility of MARAS, it is compared with state-of-the-art techniques and evaluated via case studies on datasets collected by U.S. Food and Drug Administration Adverse Event Reporting System (FAERS).

Link this page

Would you like to put a link to this lecture on your homepage?
Go ahead! Copy the HTML snippet !

Write your own review or comment:

make sure you have javascript enabled or clear this field: