Novel reagents to bypass limitations of existing clotting assays

author: Rinku Majumder, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill
published: Oct. 10, 2010,   recorded: September 2010,   views: 3500
Categories

Slides

Related content

Report a problem or upload files

If you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.
Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Lecture popularity: You need to login to cast your vote.
  Delicious Bibliography

Description

Blood clotting is the mean by which the body protects the integrity of blood vessels. Clinical tests, or clotting assays, are regularly performed to characterize bleeding disorders such as hemophilia A and B but are currently limited due to interferences present in the blood of some patients. There is a pressing need to develop a coagulation assay that is reproducible, reliable and that can be used for patients containing Lupus agents. Based on several decades of basic research in the regulation of the prothrombinase complex, which consists of a serine protease, factor Xa (FXa), and a protein cofactor, factor Va (FVa) by water soluble Phosphatidyl Serine (PS), we have developed and started to study an exciting novel PS compound containing saturated diacyl chains of only six carbons (C6PS). Using this soluble PS molecule, we have been able under ceratin circumstances to bypass the limitations caused by lupus anticoagulants and we have already obtained an US Patent for this novel reagent. Successful development of this assay will decrease misdiagnoses of bleeding disorders and will remove the need for expensive subsequent testing.

See Also:

Download slides icon Download slides: kolokviji_majumder_nrbl_01.pdf (3.3 MB)


Help icon Streaming Video Help

Link this page

Would you like to put a link to this lecture on your homepage?
Go ahead! Copy the HTML snippet !

Write your own review or comment:

make sure you have javascript enabled or clear this field: