Inferring gene regulatory networks using ensembles of feature selection techniques
published: Oct. 23, 2012, recorded: September 2012, views: 3249
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Description
Motivation: One of the long-standing open challenges in computational systems biology is the
inference of gene regulatory networks from expression data. Recently, two community-wide efforts
have been established to benchmark network inference techniques (DREAM4 and DREAM5), where
it was shown that a feature selection method us- ing variable importance scores obtained from tree-based ensemble methods (GENIE3) achieved top performance. Despite the success of this
algorithm, little research has been carried out to understand why this approach works so well, and
if equally good or better results could be obtained using other types of feature selection
techniques.
Results: In this work, we present a large scale analysis of feature selection approaches to the
network inference problem. We show that, using the recent concept of ensemble feature selection
techniques, equally good or better results than GENIE3 can be achieved, demonstrating that the
ensemble setting is a necessary requirement for feature selection techniques to achieve good
performance on the network inference task. Furthermore, we show that by combining several
ensemble feature selection techniques the performance can be made more robust and slightly
improved. This analysis opens up new avenues for the development of novel types of ensemble
based feature selection techniques in this setting.
Availability: R source code of all methods can be downloaded at
http://studwww.ugent.be/~jruyssun/FS/
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