Predicting co-evolving pairs in Pfam using information theory where entropy is determined by phylogenetic mutation events
author: Scooter Willis,
University of Florida
published: Feb. 25, 2007, recorded: June 2006, views: 3320
published: Feb. 25, 2007, recorded: June 2006, views: 3320
Related content
Report a problem or upload files
If you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Description
The accurate prediction of co-evolving pairs in protein sequences plays an important role in tertiary protein structure prediction and protein engineering. Using information theory to detect co-evolving pairs is impacted by the phylogenetic effect on entropy measurements. Mutual Information (MI) is used to detect co-evolving pairs in a protein family by re-sampling based on mutation events in the phylogenetic tree (RPE).
Link this page
Would you like to put a link to this lecture on your homepage?Go ahead! Copy the HTML snippet !
Write your own review or comment: