Wolters Kluwer aims to provide professionals with timely, more informed, actionable expert insights which can be easily integrated into their workflow and daily routines. It is no longer sufficient to have content as the main focus of Wolters Kluwer solutions with semantics and metadata as secondary concerns. It has become readily apparent that content curation and business processes need to become more knowledge-centric, i.e., to “semantify” the content and the business. To semantify content, we describe how we have developed an enterprise upper ontology based on industry standards and have developed a process to make domain-specific extensions to that ontology. With regards to our business processes, we outline how we are driving a transformational change in editorial staff and developers alike to semantify content curation and development efforts. Providing knowledge-driven expert solutions requires both of these fundamental transformations; it is not sufficient to semantify content without also changing the way the business works, and vice versa.