Odlični v znanosti 2017 - serija vsakoletnih dogodkov, ki jih organizira Javna agencija za raziskovalno dejavnost RS (ARRS) / Excellent in Science 2017 - a series of yearly events organised by the Slovenian research Agency

Nova metoda za pripravo fluoriranih kiralnih alkoholov

author: Barbara Mohar, Kemijski inštitut Ljubljana
published: Dec. 8, 2017, recorded: October 2017, views: 612

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Description

Vpeljava fluorovih atomov v organske molekule lahko ugodno vpliva na njihovo biološko delovanje zaradi spremembe fizikalno-kemijskih in presnovnih lastnosti. Zlasti kiralni fluorirani alkoholi pridobivajo na pomembnosti npr. pri razvoju zdravil proti AIDSu (Efavirenz) in depresiji (Befloksaton), pa tudi kot napredni materiali za optoelektroniko ali kot kiralni reagenti. V svojem delu so raziskovalke in raziskovalci predstavili učinkovito in praktično pripravo doslej nedostopnih enantiomerno in diastereomerno čistih CF3-substituiranih diolov s tremi kiralnimi centri.

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