The automotive and transportation industry is going through a tectonic shift in the next decade with the advent of Connectivity, Automation, Sharing, and Electrification (CASE). Autonomous driving presents a historical opportunity to transform the academic, technological, and industrial landscape with advanced sensing and actuation, high definition mapping, new machine learning algorithms, smart planning and control, increasing computing powers, and new infrastructure with 5G, cloud and edge computing. Indeed, we have witnessed unprecedented innovation and activities in the past five years in R&D, investment, joint ventures, road tests and commercial trials, from auto makers, tier-ones, and new forces from the internet and high-tech industries.